DNA ‘Smart Glue’ May Help Build 3D Tissues, OrgansJanuary 15, 2015
DNA strands can act as a glue to hold together 3-D-printed materials that could someday be used to grow tissues and organs in the lab, a new study has found.
Researchers from the University of Texas at Austin said that although scientists have used nucleic acids such as DNA to assemble objects, most of these are nano-sized and so tiny that humans can’t see them with the naked eye. Making them into larger, visible objects is cost-prohibitive. Current methods also do not allow for much control or flexibility in the types of materials that are created, researchers say.
Overcoming these challenges could potentially have a big payoff: the ability to make tissues to repair injuries or even to create organs for the thousands of patients in need of organ transplants.
Researchers set out to create a larger, more affordable material held together with DNA.
They developed DNA-coated nanoparticles made of either polystyrene or polyacrylamide. DNA binding adhered these relatively inexpensive nanoparticles to each other, forming gel-like materials that they could extrude from a 3D printer.
The materials were easy to see and could be manipulated without a microscope. The DNA adhesive also allowed the researchers to control how these gels came together.
The study showed that human cells could grow in the gels, which is a step toward the ultimate goal of using the materials as scaffolds for growing tissues. The research is published in the journal ACS Biomaterials Science & Engineering.
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