Team turning egg whites into bio-ink for tissue engineering
Marie Donlon
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August 14, 2024
A team of researchers from California-based Terasaki Institute is using egg whites to create bio-ink for tissue engineering, which is the process of creating new tissues — similar to those found in human bodies — for healing injuries or designing organs to replace damaged ones.
Specifically, the team is turning regular egg whites into a substance called egg white methacryloyl (EWMA) for use as bio-ink to 3D print tissues, layer by layer. This bio-ink is expected to offer a supportive environment for living cells to attach to and subsequently multiply.
Source: Terasaki Institute
To create the bio-ink, the team used a process that involved transforming ordinary egg whites, which are made up primarily of proteins, into a material appropriate for 3D bioprinting. The proteins were chemically altered by inserting methacryloyl groups into their structure — a process called methacryloylation. This reportedly resulted in a bio-ink that, when exposed to light, encouraged the methacryloyl groups to react and create strong crosslinks. The researchers added that the crosslinks then formed a gel-like structure that solidified the bio-ink into a 3D shape.
“This EWMA bioink offers several advantages that make it suitable for bioprinting applications. It provides abundant proteins, ensuring a nutrient-rich environment for cell growth. This bioink exhibits excellent biocompatibility and bioactivity, crucial for successful tissue engineering,” the researchers explained.
Further, the bio-ink contains antiviral and antibacterial capabilities, which are essential for infection prevention in medical applications.
An article detailing the team’s findings, “Egg White Photocrosslinkable Hydrogels as Versatile Bioinks for Advanced Tissue Engineering Applications,” appears in the journal Advanced Functional Materials.