An international team of scientists is calling for researchers to investigate the possibility that ingredients in over-the-counter mouthwash could potentially cut the transmission of SARS-CoV-2, the strain of coronavirus that is responsible for COVID-19.

Following a review of previous research that suggests the ingredients in over-the counter mouthwash might halt the transmission of viruses similar to SARS-CoV-2, a coalition of scientists from Cardiff University, the University of Nottingham, the University of Colorado, the University of Ottawa, the University of Barcelona, and Cambridge’s Babraham Institute is calling for research into the possibility that mouthwash would also destroy SARS CoV-2 based on their similar constructs.

Like the viruses explored in previous research, the SARS-CoV-2 virus is surrounded by a fatty (lipid) membrane. That earlier research suggested that mouthwash ingredients — particularly, low amounts of ethanol, povidone-iodine and cetylpyridinium — could disrupt the lipid membranes of those similar enveloped viruses. As such, the team of scientists wants to determine if that theory extends to SARS-CoV-2.

To do this, the team recommends evaluating different formulations of mouthwash in the lab and then eventually in clinical trials where populations are monitored while using commercially available mouthwash brands.

According to lead author Professor Valerie O’Donnell, co-director of Cardiff University’s Systems Immunity Research Institute, “Safe use of mouthwash — as in gargling — has so far not been considered by public health bodies in the U.K. In test-tube experiments and limited clinical studies, some mouthwashes contain enough of known virucidal ingredients to effectively target lipids in similar enveloped viruses.

“What we don’t know yet is whether existing mouthwashes are active against the lipid membrane of SARS-CoV-2. Our review of the literature suggests that research is needed as a matter of urgency to determine its potential for use against this new virus.”

The research appears in the journal Function.

To contact the author of this article, email mdonlon@globalspec.com