Oyster-inspired adhesive bonds broken bones, potentially replacing metal implants
Marie Donlon | October 05, 2025An oyster-inspired medical glue designed to repair bones has been developed by a team of Chinese researchers from Zhejiang University.
The medical adhesive, dubbed “Bone-02,” is designed to repair broken bones quickly and without the need for metal plates, screws or major surgeries.

According to its developers, the new adhesive can be injected directly into a fracture site to expedite bone repair, bonding bone fragments together in about two to three minutes, even in blood-rich environments where the majority of adhesives fail.
Making this possible, the team explained, is that the adhesive mimics how oysters adhere to underwater surfaces. This inspired the idea because bones, like oysters, reside in environments that are moist and tend to be difficult for adhesives to attach. However, oysters can attach to rocks, bridge pilings or even each other in the harsh underwater environment thanks to secreting a protein-rich adhesive called bio-cement.
This adhesive reportedly works in wet, salty and constantly moving environments, creating a tough bond that resists both pressure and erosion. Finding that oyster adhesives form a strong chemical interaction with surfaces and quickly hardens, the team sought to mimic this mechanism.
Bone-02 sets firmly within the body’s moist, blood-rich environment and demonstrated properties such as withstanding significant forces before failing. During trials, the glue reportedly demonstrated a bonding strength of over 400 lb.
Additionally, it demonstrated a shear strength of 0.5 megapascals (MPa) as well as 10 MPa of compressive strength, thereby making it resistant to crushing.
The team noted that the glue is also biodegradable, which means that the body absorbs it as the bone heals and it could possibly eliminate the need for permanent implants in certain cases.
Instead of rebuilding shattered bones with plates and screws, the team suggests that bones could essentially be “glued” back together and heal naturally.
I remember reading a few year ago about an adhesive made from soybean protein that duplicated the properties of barnacles.
The soybean protein was modified chemically and was easy to do.
I haven't heard much about it since
The glue is waterproof and extremely strong. It was sold exclusively to plywood and furniture manufactures, and I could not get a sample for my wood working projects. It is water water poof, even when boiled in water the plywood samples did not lose bonding strength. Marine plywood with this adhesive would be fantastic.
That would be great if it is bio compatible for use in dentistry. The main reason crowns fail is because of moisture loosening the adhesive that is used.
A lot of modern developments are derived from nature.
The best lubricant is whale oil from the sperm whale.
A natural duplicate is Jojoba bean bean oil, identical in every way.
Nature will exploit that which works so it is not surprising and may be found in other places as well.