A new throughput solution and attendant software from Thermo Fisher Scientific Inc. are engineered to bolster precise blood genotyping in clinical research. The Applied Biosystems Axiom BloodGenomiX Array detects most extended and rare blood groups, tissue (HLA) and platelet (HPA) types in a single, high-throughput assay.

The system improves the accuracy of match and tissue types ahead of transfusions through precision blood typing and is intended to support advancements in donor blood matching for extended phenotypes. The Axiom BloodGenomiX Array covers more than 40 genes and 260 antigens across 38 blood group systems,Source: Thermo Fisher Scientific Inc. in addition to HLA and HPA types.

In a validation study involving 14,000 diverse DNA samples collected from national blood services worldwide, the array demonstrated a 99.89% level of concordance with participants’ blood group antigen types. Automated analysis, reporting and quality control are facilitated by coupling the BloodGenomiX Array can be coupled with Applied Biosystems BloodGenomiX Reporter Software and the Applied Biosystems GeneTitan MC Instrument.

The GeneTitan MC Fast Scan Instrument automates array processing from target hybridization to data generation by combining a hybridization oven, fluidics processing, and a state-of-the art imaging device into a single bench-top instrument. The imaging device incorporated uses an external, high-intensity xenon lamp and dual excitation and emission filters to capture images from array plates for use in expression, genotyping and microbiome studies.