Pharmaceutical polymer maker TissueGen Inc. has unveiled its Elute “bioresorbable” fibers.

The biodegradable, drug-loaded fibers provide structural support for organs and arteries through medical dressings and internal prosthetics. As the fibers dissolve, they can deliver drugs, vaccines, and even cells or live viruses to the body exactly where needed.

Elute biodegradable, drug-loaded fiber. Source: TissueGen Inc.Elute biodegradable, drug-loaded fiber. Source: TissueGen Inc.The biotechnology behind the fibers advances the medical textiles market as the material has the ability to provide nerve regeneration, blood vessel repair, enhance bone growth and promote wound healing.

TissueGen’s patented extrusion process works at room temperature and enables delivery of a range of pharmaceuticals and biological agents directly to targeted internal sites via the Elute fibers. The fibers can be tailored for delivery of a range of therapeutics from small pharmaceuticals to protein-class drugs such as enzymes, growth factors, and even viral particles.

Drugs incorporated in the fiber at the time of extrusion enable implantable medical devices to meet demanding performance requirements using commercially available polymers such as polylactide, PLLA, polyglycolide, PGA, polydioxanone, PDO, or even a proprietary material.

The Elute fibers may also be loaded with biologically derived agents such as peptides and protein-class drugs including growth factors, enzymes, cytokines, carbohydrates and oligonucleotides.

TissueGen is experienced loading sensitive growth factors such as Nerve Growth Factor (NGF), Vascular Endothelial Growth Factor (VEGF) and other sensitive biological molecules including immune proteins, enzymes and even live viruses. These sensitive therapeutic agents are often requested for advanced research applications to serve as scaffolding in regenerative medical applications.

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