Biopharmaceutical processes require reliable analytical methods to ensure product safety, quality and productivity. However, conventional methods depend on opening the bioreactor when extracting a sample or compromising the sterile boundary when inserting a probe, which increases the risk of contamination. With Schott ViewPort process analytical technology (PAT) components, continuous in-situ measurement is possible without penetrating the bioreactor barrier.

The components enable in situ bioprocess monitoring without compromising the sterile boundary. Source: SchottThe metal conduit acts as a receptacle and optical interface for sensors or spectrometers and features a tightly sealed optical window consisting of sapphire, which enables real-time process monitoring. These highly transmissive optical windows support safe and sterile in situ process control. The components are available as standard variants for multi-use bioreactors as well as customized versions for single-use bioreactors.

Online spectroscopy and other optical sensors are able to further improve bioprocess monitoring. By integrating sterilizable Schott ViewPort receptacles on bioreactors, pharma companies can use advanced optical sensing technology for reliable and automated analysis. This supports safety, yield and automation level of bioprocesses as even small deviations can be detected at an early stage and adapted.

The PAT components are suitable for bioreactors of varying sizes and include a standard port diameter and flange size for easy integration into existing systems and designs. A secure connection to standard and customized ports of bioreactors allows for easy sterilization processes, such as steam-in-place of the bioreactor, including the integrated Schott ViewPort.

The components are manufactured using materials according to pharma industry best practices. These include premium steel, glass, sapphire and polymer, and feature an individual code for supporting GMP requirements. One spectrometer can be used to monitor multiple bioreactors for enhanced cost and time efficiency.

Schott is collaborating with the spectroscopy manufacturer tec5 to offer compatible user-friendly systems, consisting of the spectroscopy module from tec5 and the Schott ViewPort sensor receptacle.