Researchers from Binghamton University are developing a paper-based biosensor that promises pain-free diabetes monitoring using sweat.

According to its developers, the new paper-based biosensor system uses Bacillus subtilis bacterial spores, which germinate in the presence of glucose found in potassium-rich bodily fluids like sweat. The team added that the generated power corresponds to the glucose level.

Source: Binghamton UniversitySource: Binghamton University

Unlike current glucose monitoring systems, which rely on enzymatic reactions to blood droplets, the new paper-based system is shelf-stable for easy shipment and storage thanks to the self-replicating nature of the bacteria, which ensures longevity.

"The problem with using enzymes is that they denature and deactivate," the researchers explained. "You need to store it in a refrigerator, but even then, their potency goes down over time. Our spore-based system can endure very harsh environments and activates only when the right conditions are met."

The researchers acknowledge challenges with varying potassium levels in sweat and lower sensitivity compared to traditional biosensors but highlight the promise of developing the new glucose detection mechanism.

An article detailing the findings, Revolutionary self-powered transducing mechanism for long-lasting and stable glucose monitoring: achieving selective and sensitive bacterial endospore germination in microengineered paper-based platforms,” appears in the journal Microsystems & Nanoengineering.

To contact the author of this article, email mdonlon@globalspec.com