Chlorfenapyr, a new insecticide class for combating mosquitoes for public health, has been repurposed by engineers from BASF (Limburgerhof, Germany) for use in insecticide-treated mosquito nets. Interceptor® G2, a long-lasting insecticide-treated mosquito net (LN), earned a recommendation from the World Health Organization (WHO), the first in 30 years for a product based on a new insecticide class.
A second chlorfenapyr product, an indoor residual spray named Sylando® 240SC, is also in the final phases of WHO evaluation.
More than 200 million new cases of malaria plague the planet every year. Long-lasting insecticide-treated mosquito nets and indoor residual sprays are the cornerstones of malaria prevention, particularly in sub-Saharan Africa. But 60 countries have already reported resistance to at least one class of insecticide used in them. Only one previously approved insecticide class, the pyrethroids, was recommended for LNs, and continual use of the same chemical enabled the mosquito to develop significant levels of resistance.
Independent trials in Benin, Burkina Faso, Tanzania and the Ivory Coast have proven the efficacy of Interceptor G2 and Sylando 240SC against local insecticide-resistant mosquitoes. Depending on local registration processes, the new mosquito net is expected to be available to health ministries and aid organizations starting toward the end of this year.
Researchers from the Innovative Vector Control Consortium and the London School of Hygiene & Tropical Medicine also collaborated in this development.